Center of Research for Lung Disease

Click on the Clinical Research Trials Update for information about current research studies at the Temple Lung Center.


RESEARCH FOCUS

LOTT: Long Term Oxygen Treatment Trial
www.lottsite.org
INVESTIGATOR: Gerard Criner, MD
COORDINATOR: Carla Grabianowski/Tylenea Jones
Description: Determine the effectiveness of long term, 24-hour continuous oxygen therapy in COPD patient with moderate hypoxemia at rest
Inclusion Criteria: COPD; >10 pack-year smoking history; >40 years; post-bronchodilator FEV1/FVC < 0.70, FEV1 ² 65%; oxygen saturation 89-93% at rest
Duration: 4 years
Study: 11842


PROGRAM HIGHLIGHTS 

A history of ground-breaking research

  • Performed first prospective randomized trial of lung volume reduction surgery1 and helped lead National Emphysema Treatment Trial comparing LVRS with standard medical care2
  • Developed first registry-based description of outcomes in pulmonary hypertension3
  • Chosen by Medicare as one of only three U.S. sites to test the value of specialized care for mechanically ventilated patients
  • Performed first investigation of alpha-1 antitrypsin deficiency4
  • Over 15 years, completed >25 studies testing new therapies for COPD and published hundreds of peer-reviewed articles on pulmonary disease

One of the most active and innovative research programs in the nation

  • Participating in or leading over a dozen COPD trials, including testing of less invasive procedures, steroids, and bronchodilators as well as novel anti-inflammatories, antibiotics, and vaccines
  • Member of NHLBI COPD Clinical Research Network
  • Leading several clinical trials of novel agents in pulmonary hypertension
  • Coordinating Pennsylvania Idiopathic Pulmonary Fibrosis State Registry
  • Coordinating Mid-Atlantic states in 6-year NIH study of supplemental oxygen therapy (LOTT) for moderate COPD
  • Leading major Pennsylvania-wide study evaluating best methods to prevent full-blown COPD exacerbations (PA-SCOPE)
  • Participating in largest study of COPD ever undertaken—aimed at determining genetic and other underlying causes of COPD (COPD-Gene)
  • At the Spring 2007 meeting of the American Thoracic Society, Temple clinicians presented over 20 abstracts on COPD, lung transplantation, or LVRS

References

  1. Criner GJ et al. Am J Respir Crit Care Med 1999;160:2018-2027
  2. Fishman A et al. N Engl J Med 2003;348:2059-2073
  3. D’Alonzo GE et al Ann Intern Med 1991;115:343-349
  4. Kueppers F Am J Hum Genet 1976;28:370-377

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