Center for Research of Lung Disease

For printable information about current research trials at the Temple Lung Center, please click here (PDF)


PROGRAM HIGHLIGHTS 

A history of ground-breaking research

• Performed first prospective randomized trial of lung volume reduction surgery¹ and helped lead National Emphysema Treatment Trial comparing LVRS with standard medical care²
• Developed first registry-based description of outcomes in pulmonary hypertension³
• Chosen by Medicare as one of only three U.S. sites to test the value of specialized care for mechanically ventilated patients
• Performed first investigation of alpha-1 antitrypsin deficiency⁴
• Over 15 years, completed >25 studies testing new therapies for COPD and published hundreds of peer-reviewed articles on pulmonary disease

One of the most active and innovative research programs in the nation

• Participating in or leading over a dozen COPD trials, including testing of less invasive procedures, steroids, and bronchodilators as well as novel anti-inflammatories, antibiotics, and vaccines
• Member of NHLBI COPD Clinical Research Network
• Leading several clinical trials of novel agents in pulmonary hypertension
• Coordinating Pennsylvania Idiopathic Pulmonary Fibrosis State Registry
• Coordinating Mid-Atlantic states in 6-year NIH study of supplemental oxygen therapy (LOTT) for moderate COPD
• Leading major Pennsylvania-wide study evaluating best methods to prevent full-blown COPD exacerbations (PA-SCOPE)
• Participating in largest study of COPD ever undertaken—aimed at determining genetic and other underlying causes of COPD (COPD-Gene)
• At the Spring 2007 meeting of the American Thoracic Society, Temple clinicians presented over 20 abstracts on COPD, lung transplantation, or LVRS
  

References

1. Criner GJ et al. Am J Respir Crit Care Med 1999;160:2018-2027
2. Fishman A et al. N Engl J Med 2003;348:2059-2073
3. D’Alonzo GE et al Ann Intern Med 1991;115:343-349
4. Kueppers F Am J Hum Genet 1976;28:370-377

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